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Ten selected Publications

• Mösslein, N., Pohle, L. G., Fuss, A., Bünemann, M. & Krasel, C. (2022)
  Residency time of agonists does not affect the stability of GPCR-arrestin complexes.
  Br. J. Pharmacol., in press
  PMID: 35352338.
  https://doi.org/10.1111/bph.15846
  
  
• Gillis, A., Gondin, A. B., Kliewer, A., Sanchez, J., Lim, H. D., Alamein, C., Manandhar, P., Santiago, M., Fritzwanker, S., Schmiedel, F., Katte, T. A., Reekie, T., Grimsey, N. L., Kassiou, M., Kellam, B., Krasel. C., Halls, M. L., Connor, M., Lane, J. R., Schulz, S., Christie, M. J. & Canals M. (2020)
  Low intrinsic G protein efficacy can explain the improved side effect profile of novel opioid ligands.
  Sci. Signal. 13: eeaz3140.
  PMID: 32234959.
  https://doi.org/10.1126/scisignal.aaz3140
  
  
• Miess, E., Gondin, A. B., Yousuf, A., Steinborn, R., Mösslein, N., Yang, Y., Göldner, M., Ruland, J. G., Bünemann, M., Krasel, C., Christie, M. J., Halls, M. L., Schulz, S. & Canals, M. (2018)
  Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid µ-opioid receptor desensitization.
  Sci. Signal. 11: eeas9609.
  PMID: 30018083.
  https://doi.org/10.1126/scisignal.aas9609
  
  
• Zindel, D., Engel, S., Bottrill, A. R., Pin, J.-P., Prézeau, L., Tobin, A. B., Bünemann, M., Krasel, C.* & Butcher, A. J.* (2016)
  Identification of key phosphorylation sites in PTH1R which determine arrestin3 binding and fine tune receptor signaling.
  Biochem. J. 473, 4173-4192.
  PMID: 27623777.
  https://doi.org/10.1042/BCJ20160740
  
  
• Zindel, D., Butcher, A. J., Al-Sabah, S., Lanzerstorfer, P., Weghuber, J., Tobin, A. B., Bünemann, M. & Krasel, C. (2015)
  Engineered hyperphosphorylation of the beta(2)-adrenoceptor prolongs arrestin-3 binding and induces arrestin internalization.
  Mol. Pharmacol. 87, 349-362.
  PMID: 25425623.
  https://doi.org/10.1124/mol.114.095422
  
  
• Al-Sabah, S., Al-Fulaij, M., Shaaban, G., Ahmed, H. A., Mann, R. J., Donnelly, D., Bünemann, M. & Krasel, C. (2014)
  The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively.
  PLoS One 9, e106890.
  PMID: 25191754.
  https://doi.org/10.1371/journal.pone.0106890
  
  
• McPherson, J., Rivero, G., Baptist, M., Llorente, J., Al-Sabah, S., Krasel, C., Dewey, W. L., Bailey, C. P., Rosethorne, E. M., Charlton, S. J., Henderson, G. & Kelly, E. (2010)
  μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.
  Mol. Pharmacol. 78, 756-766.
  PMID: 20647394
  https://doi.org/10.1124/mol.110.066613
  
  
• Krasel, C., Zabel, U., Lorenz, K., Reiner, S., Al-Sabah, S. & Lohse, M. J. (2008)
  Dual role of the beta(2)-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization.
  J. Biol. Chem. 283, 31840-31848.
  PMID: 18801735
  https://doi.org/10.1074/jbc.M806086200
  
  
• Krasel, C., Bünemann, M., Lorenz, K, & Lohse, M. J. (2005)
  Beta-arrestin binding to the beta(2)-adrenergic receptor requires both receptor phosphorylation and receptor activation.
  J. Biol. Chem. 280, 9528-9535.
  PMID: 15634674.
  https://doi.org/10.1074/jbc.M413078200
  
  
• Vilardaga, J.P, Bünemann, M., Krasel, C., Castro, M.& Lohse, M.J. (2003)
  Measurement of the millisecond activation switch of G protein-coupled receptors in living cells.
  Nat Biotechnol. 21: 807-12.
  PMID: 12808462.
  https://doi.org/10.1038/nbt838